Botulinum Toxin and the Treatment of Primary Disorders of Mood and Affect
AssigneeBotulinum Toxin Research Associates, Inc.
InventorGary E. Borodic
Life of this patent
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Abstract
A method of treating anxiety disorder comprising the steps of: identifying a subject with one or more symptoms of an anxiety disorder; a botulinum toxin to soft tissues outside the neurocranium using an injection selected from the group consisting of: a transdermal injection; a subcutaneous injection; and a percutaneous injection; and thereby reducing at least one symptom of anxiety disorder.
Claims44
-9. (canceled)
A method of treating anxiety comprising the steps of:
- or identifying a subject with at least one symptom of an anxiety disorder;
- and administering an effective amount of a composition comprising a botulinum toxin to soft tissue outside a neurocranium of said subject using at least one of:
- a transdermal injection, a subcutaneous injection, an osseous injection and a percutaneous injection delivering at least a portion of the botulinum toxin to a central nervous system of said subject, thereby reducing at least one symptom of anxiety.
-14. (canceled)
(canceled)
-60. (canceled)
A method of treating an anxiety disorder comprising the steps of:
- identifying a subject with one or more symptoms of an anxiety disorder;
- administering to at least one soft tissue region outside a neurocranium of said subject a composition comprising a botulinum neurotoxin wherein said composition is diffused across a blood brain barrier in an amount sufficient to at least one central nervous system neurotransmitter comprising at least one of:
- glutamate, acetylcholine, GABA, nor epinephrine and corresponding receptors.
-64. (canceled)
The method of claim 64, wherein said botulinum neurotoxin is immunotype A, B, C, D, E, F, or G.
-67. (canceled)
-70. (canceled)
-115. (canceled)
A method of suppressing central nervous system neurotransmission with the central nervous system in a mammal comprising:
- injecting a botulinum toxin composition into a soft tissue region outside the neurocranium;
- diffusing at least a portion of the botulinum toxin composition across the blood brain barrier, wherein the portion of the botulinum toxin composition reaches the central nervous system;
- and
- blocking at least one neurotransmitter.
A method of treating a psychological trauma disorder in a mammal characterized as post-traumatic stress syndrome, the method comprising the steps of administering to the mammal a therapeutically effective amount of a composition including botulinum neurotoxin to at least one of the extra cranial regions of the head and neck wherein the administration of the composition reduces a symptom of the psychological trauma disorder.
Dependencies are inferred from the claim text.