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AssigneesUniversite D'Angers, Universite De Poitiers, Bioalternatives SAS
InventorsJean-Claude Lecron, Hughes Gascan, Franck Morel, Sylvie Chevalier, Francois-Xavier Bernard, Katia Boniface, Caroline Diveau
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The invention disclosed herein relates to the field of epidermal repair and skin innate immunity. More particularly, the invention concerns the use of a mix of cytokines to inhibit keratinocyte differentiation, activate skin innate immunity, increase the expression of anti-microbial peptides, and improve epidermal repair. In particular, the invention concerns compositions comprising at least IL-17, TNFα and OSM that can be formulated for topical administration for cosmetic or dermatologic use.
A method for improving cutaneous innate immunity, comprising administering a composition comprising IL-1α, IL-17, TNFα, oncostatin M (OSM) and IL-22 to a patient in need thereof.
A method for increasing the expression of anti-microbial peptides by keratinocytes, comprising contacting said keratinocytes with a composition comprising IL-17, TNFα and OSM.
A composition comprising IL-1α, IL-17, TNFα, IL-22 and OSM.
Dependencies are inferred from the claim text.