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US 2015/0086480 A1Published application
Heteroaryl inhibitors of pde4
AssigneeTetra Discovery Partners, LLC
InventorsEmily Catherine D'Amato, Mark Gurney, Xuesheng Mo, Richard A. Nugent
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Abstract
The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
Claims38
A compound of Formula I
- or a salt thereof, wherein:
- X is chosen from O, NH, NR3, and C(R3)2;
- R1 and R2 are each independently chosen from aryl and heteroaryl, either of which may be optionally substituted;
- and
- each R3 is independently chosen from hydrogen and lower alkyl.
2 more elements
The compound of Example 1.
Dependencies are inferred from the claim text.