Sterilization pouch with internal and external indicators

A sterilization package comprising:

• a first package layer;
• a second package layer coupled to the first package layer with a perimeter seal extending around a portion of the sterilization package to define a pouch having a proximal end and a distal end, the pouch including a sealable opening at the proximal end;
• a first steam sterilization indicium printed on the second package layer exterior of the pouch and proximate the distal end of the pouch, the first sterilization indicium on a side of the second package layer facing the first package layer;
• and
• a second steam sterilization indicium printed on the second package layer interior of the pouch and proximate the distal end of the pouch, the second sterilization indicium on a side of the second package layer facing the first package layer,
• wherein at least one of the first and second steam sterilization indicia is a multi-parameter steam sterilization indicium that is configured to change from a first color to a second color when the sterilization package is subjected to complete sterilization conditions with respect to at least two sterilization process variables selected from the group consisting of time, temperature, and presence of steam.