Fermentation process for the production of rapamycin
AssigneeNatco Pharma Limited
InventorsBaby Rani Polavarapu, Suneel Kumar Battula, Kali Satya Bhujanga Rao Adibhatla, Venkaiah Chowdary Nannapaneni
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Abstract
The present invention provides a novel method for producing rapamycin by submerged fermentation which comprises cultivating Streptomyces hygroscopicus (CBS 773.72) and mutants thereof. The present invention provides a high yielding mutant culture MTCC5681 from Streptomyces hygroscopicus CBS 773.72. This culture is capable of producing rapamycin more efficiently than the cultures Streptomyces hygroscopicus from sources like ATCC, NRRL etc which have been reported so far.
Claims14
1-12. (canceled)
A mutant strain Streptomyces hygroscopicus MTCC 5681.
A process for the manufacture of rapamycin comprising steps of:
- i. preparing an inoculum of a mutant strain Streptomyces hygroscopicus MTCC 5681;
- ii. developing the seed stages with the said inoculum;
- iii. inoculating the said matured seed to fermenter to obtain rapamycin.
A process for producing rapamycin which comprises culturing in a nutrient medium a mutant strain capable of producing rapamycin, wherein said mutant strain is Streptomyces hygroscopicus MTCC 5681 under submerged fermentation conditions.
Dependencies are inferred from the claim text.