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US 2015/0073138 A1Published application
Novel process for preparing ceftaroline fosamil
AssigneeSandoz Ltd.
InventorsPeter Kremminger, Hubert Sturm
Life of this patent
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Abstract
The present invention relates to a novel process for preparing ceftaroline fosamil as well as to a intermediates of this process.
Claims13
A compound selected from the group consisting of
- wherein
- R is R1—C(O)— with R1 being C1-12 alkyl or R2—O—C(O)— with R2 being C1-4 alkyl, benzyl or phenyl;
- and
- Y⊖ is an anion.
1 more element
(canceled)
A process comprising:
- (i) providing a compound having the formula (1), (3) or (4)
- wherein
- R is R1—C(O)— with R1 being C1-12 alkyl or R2—O—C(O)— with R2 being C1-4 alkyl, benzyl or phenyl;
- and
- Y⊖ is an anion;
- (ii) reacting the compound having the formula (1), (3) or (4) with an activated form of a compound having the formula (5)
- to provide a compound having the formula (6)
4 more elements
A process for producing a compound having a formula (4) comprising the steps of:
- (i) reacting [4-(4-pyridyl)-1,3-thiazol-2-yl]thiol with an acylating agent to provide a compound having the formula (ii)
- wherein R is R1—C(O)— with R1 being C1-12 alkyl or R2—O—C(O)— with R2 being C1-4 alkyl, benzyl or phenyl;
- and
- (ii) reacting the resultant compound having the formula (ii) with a methylating agent to provide the compound having the formula (4)
- (iii).
2 more elements
A process of preparing a compound having the formula (3) comprising the steps of:
- (i) reacting 4-acetyl-1-methylpyridinium salt to provide 4-(2-halogenoacetyl)-1-methylpydridinium halogenide;
- and
- (ii) reacting the resultant 4-(2-halogenoacetyl)-1-methylpydridinium halogenide with a dithiocarbamate to provide the compound having the formula (3).
- wherein Y⊖ is an anion.
1 more element
A process for producing a compound having the formula (3) as comprising the steps of:
- (i) reacting [4-(4-(1-methylpyridyl)-1,3-thiazol-2-yl]thiolate with an acid HY to provide a compound having the formula (3).
- wherein Y⊖ is an anion
(canceled)
Dependencies are inferred from the claim text.