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US 2015/0064146 A1Published application
Blood Brain Barrier Device
AssigneeSearete LLC
InventorsEd Harlow, Roderick A. Hyde, Edward K.Y. Jung, Robert Langer, Eric C. Leuthardt, Lowell L. Wood, JR.
Life of this patent
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Abstract
Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
Claims20
1-78. (canceled)
A method of making a device, comprising:
- forming a semi-permeable component from endothelial cells;
- configuring the semi-permeable component to at least partially form an internal cavity;
- and
- engineering the endothelial cells to have one or more characteristics of a blood brain barrier capillary endothelium;
- wherein at least one of the one or more characteristics of the blood brain barrier capillary endothelium is not a characteristic of peripheral capillary endothelium.
2 more elements
A method for delivering one or more biologically active molecules to a subject, comprising:
- identifying the one or more biologically active molecules;
- and
- implanting in the subject one or more of the devices of claim 1;
- wherein the one or more biologically active molecules are added to the one or more devices.
1 more element
A method of assembling a device for delivering one or more biologically active molecules to a subject, comprising:
- identifying the one or more biologically active molecules;
- selecting one or more of the devices of claim 1;
- and
- providing the one or more biologically active molecules to the device.
1 more element
97-187. (canceled)
Dependencies are inferred from the claim text.