Imaging agent
AssigneeKing's College London
InventorsXianjin Cui, Philip Blower, Mark A. Green
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Abstract
The invention relates to imaging agents, and in particular to multi-modal nanoparticle (NPIA) imaging agents offering magnetic, radionuclide and fluorescent imaging capabilities to exploit the complementary advantages of magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT) and optical imaging (OI). The invention extends to these new types of agents per se, and to uses of such agents in various biomedical applications, such as in therapy and in diagnosis.
Claims37
A nanoparticle imaging agent comprising an inner magnetic core, and an outer shell disposed substantially around the core, wherein the shell is configured to be radiolabelled.
A method of preparing a nanoparticle imaging agent according to any preceding claim, the method comprising:—
- (i) heating a magnetic metal precursor in a solvent to produce a magnetic core;
- (ii) depositing a layer substantially around the magnetic core to produce an outer shell, and
- (iii) radiolabelling the shell, to produce a nanoparticle imaging agent.
Dependencies are inferred from the claim text.