Encoding of microcarriers
AssigneeMycartis NV
InventorsStefaan Cornelis De Smedt, Joseph Demeester, Christiaan Hubert Simon Roelant, Rudi Wilfried Jan Pauwels
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Abstract
Encoded microcarriers, and more specifically microcarriers having codes written on them. Methods for writing the codes on the microcarriers, methods of reading the codes, and methods of using the encoded microcarriers. A preferred method of encoding the microcarriers involves exposing microcarriers containing a bleachable substance to a high spatial resolution light source to bleach the codes on the microcarriers. The encoded microcarriers may be used, for example, as support materials in chemical and biological assays and syntheses.
Claims9
An encoded microcarrier, comprising:
- a body having a surface, wherein said body has a spherical, cylindrical or oval shape;
- a chemically etched code written on the surface of the body or at an internal depth thereof, said chemically etched code identifying the microcarrier;
- and
- one or more ligands bound to the microcarrier, wherein each ligand binds or reacts with one or more target analytes,
- wherein the identity of the ligands are correlated with the chemically etched code written on the surface of the body or at the internal depth thereof to determine the presence of or absence of one or more target analytes.
A chemical library, comprising:
- a plurality of encoded microcarriers, each encoded microcarrier including:
- a body having a surface, wherein said body has a spherical, cylindrical or oval shape,
- a chemically etched code written on the surface of the body or at an internal depth thereof, said chemically etched code identifying the microcarrier, and
- one or more ligands bound to the surface of the microcarrier;
- and
- a plurality of individual members of said chemical library, wherein said individual members are bound to said plurality of encoded microcarriers.
Dependencies are inferred from the claim text.