Recombinant inactivated viral vector vaccine
AssigneeLaboratorio Avi-Mex, S.A. De C.V.
InventorsBernardo LOZANO-DUBERNARD, David Sarfati-Mizrahi, Jesús Alejandro Suárez-Martínez, Manuel Joaquín Gay-Gutiérrez, Ernesto Soto-Priante
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Abstract
A vaccine is described, comprising an inactivated viral vector having inserted an exogenous nucleotide sequence coding for a disease of concern; and, a pharmaceutically acceptable vehicle, adjuvant or excipient, which provides due protection against the disease of concern by using a viral vector titer similar to that required for an active-virus vaccine based on the same viral vector. Mainly, viral vectors of paramixovirus or adenovirus are described.
Claims28
A method of vaccinating an animal against a disease to which said animal is susceptible, which comprises administering to said animal an immunologically effective amount of a recombinant vaccine comprising (a) an inactivated viral vector having an exogenous nucleotide sequence inserted that codes for an antigen of the pathogen causing said disease in the species to which said animal belongs, wherein the antigen is expressed in the viral surface;
- and (b) a pharmaceutically acceptable vehicle, adjuvant or excipient;
- wherein the vaccine has a potency against the disease of at least 80% that of a vaccine that is effective against the disease and comprises the inactivated whole pathogen that causes said disease in the species to which said animal belongs.
Dependencies are inferred from the claim text.