Compositions and Methods for the Maintenance of Oral Health
AssigneeOragenics, Inc.
InventorJeffrey D. Hillman
Life of this patent
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Abstract
The invention provides compositions comprising one or more isolated LDH-deficient mutans streptococcus strains and one or more isolated S. oxalis strains and/or one or more isolated S. uberis strains. Compositions of the invention are useful to maintain oral health, by for example treating and/or preventing one or more symptoms of dental caries, periodontitis and/or other oral cavity diseases or wounds.
Claims16
A composition comprising:
- one or more biologically pure mutans streptococci strains selected from the group consisting of Streptococcus rattus, Streptococcus rattus strain JH145, Streptococcus cricetus, Streptococcus mutans, Streptococcus sobrinus, Streptococcus downeii, Streptococcus macacae, and Streptococcus ferus;
- wherein said mutans streptococcus strains are genetically modified strains that are lactate dehydrogenase-deficient;
- one or more biologically pure Streptococcus oralis strains;
- and one or more biologically pure Streptococcus uberis strains.
A method for maintaining oral health of a subject comprising administering a composition comprising one or more biologically pure mutans streptococci strains selected from the group consisting of Streptococcus rattus, Streptococcus rattus strain JH145, Streptococcus cricetus, Streptococcus mutans, Streptococcus sobrinus, Streptococcus downeii, Streptococcus macacae, and Streptococcus ferus;
- wherein said mutans streptococcus strains are genetically modified strains that are lactate dehydrogenase-deficient;
- one or more biologically pure Streptococcus oralis strains;
- and one or more biologically pure Streptococcus uberis strains to an oral cavity of a subject.
Dependencies are inferred from the claim text.