Sorbent comprising on its surface an aliphatic unit for the purification of organic molecules
AssigneeInstraction GmbH
InventorsMarkus Arendt, Björn Degel, Thomas Schwarz, Gerhard Stumm, Martin Welter
Life of this patent
Estimating the term…
Abstract
The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic applications
Claims15
1-14. (canceled)
A sorbent comprising a solid support material, wherein the surface of the solid support material comprises a residue of the following general formula (I):
- L-X formula (I),
- wherein the residue is attached via a covalent single bond represented by the dotted line in formula (I) to a functional group on the surface of either the bulk solid support material itself or a polymer film on the surface of the solid support material, and wherein:
- (a) L represents a covalent single bond or is a bivalent unit selected from the group consisting of —C(O)—, —S(O)2—, —CH2CH(OH)— and —C(O)NH—;
- (b) X represents a monovalent linear aliphatic hydrocarbon group comprising 1 to 30 carbon atoms, or a branched or cyclic aliphatic hydrocarbon group comprising 3 to 30 carbon atoms, wherein:
- (i) one or more CH2-moieties in said groups may be substituted by O, S, —S(O)2—, —C(O)NH— or —C(S)NH—;
- (ii) one or more hydrogen atoms may be substituted by F, Cl, Br, —CN or —NC;
- and
- (iii) said groups may comprise one or more double bonds between two carbon atoms.
Dependencies are inferred from the claim text.