Sheep nematode vaccine
AssigneeMoredun Research Institute
InventorsJacqueline Matthews, Alasdair Justice Nisbet, David Knox
Life of this patent
Estimating the term…
Abstract
The present invention is based upon the identification of a number of antigens derived from species of the genus Teladorsagia, which can be used to raise immune responses in animals—particularly those animals susceptible or predisposed to infection by (or with) one or more Teladorsagia species. The antigens may be exploited to provide compositions and vaccines for raising protective immune responses in animals—the protective immune responses serving to reduce, prevent, treat or eliminate Teladorsagia infections/infestations.
Claims31
1-27. (canceled)
A method of raising an immune response in an animal, said method comprising administering to an animal, an amount of one or more Teladorsagia antigens(s) or fragment(s) thereof, sufficient to induce an immune response.
The method of 32, wherein the antigen is administered in combination with one or more other antigens selected from the group consisting of:
- (i) calcium-dependent apyrase-1 (Tci-APY-1);
- (ii) astacin-like metalloproteinase-1 (Tci-MEP-1);
- (iii) excretory/secretory protein (unknown function:
- Tci-ES20).
- (iv) transforming growth protein 2-like protein (a TGFβ homologue:
- Tci-TGH-2);
- (v) activation associated secretory protein (Tci-ASP-1);
- (vi) macrophage migration inhibitory factor (Tci-MIF-1);
- (vii) surface associated antigen (Tci-SAA-1);
- (viii) An antigen encoded by a sequence exhibiting a degree of identity/homology with a sequence of SEQ ID NOS:
- 1, 2, 3, 4, 6, 7 or 8;
- and
- (vii) a homolog, fragment, mutant, variant or derivative of any of (i)-(viii).
A composition or vaccine comprising one or more recombinant Teladorsagia antigen(s) for raising an immune response in an animal.
A composition or vaccine comprising a recombinant T. circumcincta cathepsin F-1 (Tci-CF-1) antigen or a homolog, fragment, mutant or variant thereof, for raising and immune response in an animal.
An antibody that specifically binds to one or more of the antigens selected from the group consisting of:
- (i) cathepsin F-1 (Tci-CF-1).
- (ii) calcium-dependent apyrase-1 (Tci-APY-1),
- (iii) astacin-like metalloproteinase-1.
- (iv) excretory/secretory protein (unknown function:
- Tci-ES20).
- (v) transforming growth protein 2-like protein (a TGFβ homologue:
- Tci-TGH-2).
- (vi) activation associated secretory protein (Tci-ASP-1).
- (vii) macrophage migration inhibitory factor (Tci-MIF-1).
- (x) surface associated antigen (Tci-SAA-1);
- (xi) an antigen encoded by a sequence exhibiting a degree of homology/identity to a sequence of SEQ ID NOS:
- 5, 1, 2, 3, 4, 6, 7 or 8;
- and
- (xii) a homolog, fragment, mutant, variant or derivative of any of (i)-(viii).
Dependencies are inferred from the claim text.