Hair follicle stem cells and methods of use same
AssigneeUniversity of Southern California
InventorsKrzysztof Kobielak, Eve Kandyba
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Abstract
The disclosure provides isolated hair follicle stem cells (hfSC) having inactivated BMP signaling, which are discovered to express keratin 15. Also provided are hfSC that have constitutively activated BMP signaling and methods of using such hfSC for screening candidate agents suitable for inhibiting BMP signaling in hfSC and promoting hair growth. Further provided are methods of activating hfSC and promoting hair growth from hfSC.
Claims31
An isolated hair follicle stem cell (hfSC) that expresses keratin 15 (K15) and has decreased BMP signaling.
An isolated hair follicle stem cell (hfSC) comprising a constitutively active BMPR1A gene.
A transgenic non-human mammal comprising a hair follicle stem cell (hfSC) comprising a constitutively active BMPR1A gene.
A method of activating a hair follicle stem cell (hfSC), comprising increasing the biological activity of one or more of Wnt7a, Wnt7b, or Fzd10 and/or decreasing the biological activity of Dkk3.
Dependencies are inferred from the claim text.