Systems and methods for selecting and analyzing particles in a biological tissue
AssigneeGeneral Electric Company
InventorsVidya Pundalik Kamath, Alberto Santamaria-Pang, Brion Daryl Sarachan, Megan Rothney
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Abstract
Systems and methods are disclosed for jointly presenting and analyzing morphological characteristics and biomarker expression levels of a biological sample. The systems and methods may utilize a morphological selection component to isolate a population of biological particles in a biological sample for exclusion from further processing. In addition, the systems and methods may simultaneously render morphological and statistical representations of the biological sample on a user interface.
Claims25
A computer-implemented method for selectively displaying representations of biological units of interest in biological tissue, the method comprising:
- rendering a graphical user interface on a visual display device;
- rendering, on the graphical user interface, a field of view selection component allowing a user to select a field of view from a data set comprising tissue profile data including registered multiplexed biomarker images capturing expression of a plurality of biomarkers in a plurality of fields of view of biological tissue, wherein individual biological units in the plurality of fields of view are delineated;
- in response to user input selecting the field of view corresponding to a biological tissue at the field of view selection component, rendering, on the graphical user interface, a first image of the selected field of view corresponding to the biological tissue, the first image representing expression levels of a first biomarker and including representations of individual biological units in the biological tissue;
- and
- rendering, on the graphical user interface, a morphological feature selection component allowing a user to select from among the delineated individual biological units a first morphological feature meeting at least one first morphological feature criteria;
- in response to user input selecting a first morphological feature meeting at least one first morphological feature criteria, identifying a first set of biological units represented in the first image that meet the at least one first morphological feature criteria in the first image of the selected field of view as biological units for exclusion from further analysis.
A computer-implemented method for selectively displaying representations of biological units of interest in biological tissue, the method comprising:
- rendering a graphical user interface on a visual display device;
- simultaneously rendering, on the graphical user interface, a morphological representation and a statistical representation of a biological sample, wherein a selection a population of one or more biological units in the biological same is simultaneously reflected on both representations.
A system for selectively displaying representations of biological units of interest in biological tissue, the system comprising:
- a processor for executing computer readable instructions stored on non-transitory computer readable storage media;
- a display;
- and
- a non-transitory storage media storing computer readable instruction for:
- rendering a graphical user interface on the visual display device;
- rendering, on the graphical user interface, a field of view selection component allowing a user to select a field of view from a data set comprising tissue profile data including registered multiplexed biomarker images capturing expression of a plurality of biomarkers in a plurality of fields of view of biological tissue, wherein individual biological units in the plurality of fields of view are delineated;
- in response to user input selecting the field of view corresponding to a biological tissue at the field of view selection component, rendering, on the graphical user interface, a first image of the selected field of view corresponding to the biological tissue, the first image representing expression levels of a first biomarker and including representations of individual biological units in the biological tissue;
- and
- rendering, on the graphical user interface, a morphological feature selection component allowing a user to select from among the delineated individual biological units a first morphological feature meeting at least one first morphological feature criteria;
- in response to user input selecting a first morphological feature meeting at least one first morphological feature criteria, identifying a first set of biological units represented in the first image that meet the at least one first morphological feature criteria in the first image of the selected field of view as biological units for exclusion from further analysis.
Dependencies are inferred from the claim text.