Instruments and methods for the implantation of cell-seeded substrates
AssigneesUniversity of Southern California, California Institute of Technology, The Regents of the University of California
InventorsMark Humayun, Ashish Ahuja, Yu-Chong Tai, Robert Grubbs, Rodrigo Brant, Trent Wells, Lincoln Vallance Johnson, Sherry T. Hikita, David Hinton
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Abstract
Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
Claims21
An instrument for the implantation of a substrate into a target tissue of a subject, comprising:
- a handpiece comprising a proximal end and a distal end, said distal end comprising an orifice;
- a distal outer housing extending in a distal direction from said handpiece;
- an internal shaft having a proximal end and a distal end and configured to be longitudinally moveable within said distal outer housing and said handpiece, and
- wherein said distal-most portion said internal shaft comprises forceps;
- and
- a shaft movement control mechanism,
- wherein activation of said movement control mechanism causes longitudinal movement of said internal shaft;
- wherein movement of said internal shaft in a proximal direction causes the distal-most portion of said internal shaft to retract within the distal-most portion of the said distal outer housing, and
- wherein said retraction thereby causing said forceps to close;
- and
- wherein movement of said internal shaft in a distal direction causes the distal-most portion of said internal shaft to extend beyond the distal-most portion of the said distal outer housing thereby causing said forceps to open.
-50. (canceled)
Dependencies are inferred from the claim text.