Drug-Eluting Stent and Method
OwnerOmar Tanweer, Vittoria Flaminiinventors
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Abstract
A drug-eluting stent is disclosed, the stent having an outer cylindrical portion, an inner cylindrical portion disposed within and substantially coaxial with the outer cylindrical portion, a plurality of cross-links connecting the inner cylindrical portion to the outer cylindrical portion, and a first drug affixed to the inner and/or outer cylindrical portions. The stent may further comprise a second drug affixed to the inner and/or outer cylindrical portions. Methods are disclosed for use of a drug-eluting stent for treatment of a region of interest which is located away (downstream) from the location of the stent. Methods are disclosed for the use of the dual drug-eluting stent to provide therapy and adjunctive therapy protocols.
Claims20
A drug-eluting stent, comprising:
- an outer cylindrical portion being expandable from a first diameter for delivery into a vessel, to a second diameter for placement in the vessel, the outer cylindrical portion having an interlumen surface, an abluminal surface, and a plurality of openings extending from the interlumen surface to the abluminal surface, and the outer cylindrical portion having a first porosity;
- an inner cylindrical portion disposed within and substantially coaxial with the outer cylindrical portion, the inner cylindrical portion having a luminal surface and an interlumen surface, and a plurality of openings extending from the luminal surface to the interlumen surface, and the inner cylindrical portion having a second porosity;
- a plurality of cross-links, each cross-link connecting the outer cylindrical portion to the inner cylindrical portion, and each cross-link being collapsible such that the distance between the outer cylindrical portion and the inner cylindrical portion may vary;
- and
- a first drug affixed to at least one of the outer cylindrical portion and inner cylindrical portion.
A method of deploying a drug-eluting stent for treating a distal region of interest of an individual, comprising the steps of:
- inserting the stent into a blood vessel of the individual to an upstream, distal location with respect to the region of interest;
- causing the stent to expand such that the stent remains at the upstream location.
A method of treating a region of interest of an individual using a drug-eluting stent, the drug-eluting stent having two drugs thereon, the method comprising the steps of:
- deploying the drug-eluting stent into a blood vessel of the individual to an upstream location near the region of interest;
- and
- wherein the stent elutes a first drug and a second drug into the blood of the blood vessel such that the first drug reaches the region of interest before the second drug.
Dependencies are inferred from the claim text.