Systems and methods for sealing openings in an anatomical wall

A method of sealing openings within an anatomical wall, the method comprising:

• delivering percutaneously a puncture seal closure system within a sheath to an opening in an anatomical wall to be sealed, where the system comprises an elongate tubular support having a distal end and a proximal end, the tubular support configured for percutaneous delivery to the opening to be sealed;
• a cover of bio-compatible material configured to cover at least a portion of the tubular support from at least the distal end of the tubular support to a central portion of the tubular support, the cover material having a distal end configured to engage the distal end of the tubular support and a proximal end, the cover further comprising an anchor covering portion positioned proximate the proximal end of the cover;
• and an anchor assembly comprising a plurality of distal anchors and a plurality of proximal anchors positioned proximal the central portion of the tubular support, the distal and proximal anchors sufficiently malleable and configured to be foldable against the tubular support when in a first delivery position, and to foldable radially outwardly away from the tubular support in a second wall engagement position;
• positioned the puncture seal system in-situ within the opening so that the distal anchors are positioned along the distal side of the opening wall and the proximal anchors are positioned along the proximal side of the opening wall;
• withdrawing the sheath to permit the anchors may be positioned in the wall engagement position to secure the seal system in place;
• removing the tubular support in a proximal direction so as to draw the cover material inside-out from a distal-most position to a proximal-most position;
• severing the exposed end of the cover material with a closure member for closing off an end of the cover material after removal of the tubular support wherein the opening may sealed using the anchor covering portion of the cover material in combination with the anchors.

A system for sealing an opening within an anatomical wall, the system comprising:

• an elongate tubular support having a proximal end and a distal end, the tubular support configured for delivery into the opening to be sealed;
• an anchor assembly configured to be secured to the anatomical wall adjacent the opening, wherein the elongate tubular support is positionable in a first position within the anchor assembly wherein the proximal end of the tubular support is proximal to the anchor assembly and the distal end of the tubular support is distal to the anchor assembly;
• and
• a cover of bio-compatible material connected to the anchor assembly and configured to extend distally from the anchor assembly to cover at least a portion of the tubular support when the tubular support is in the first position;
• wherein the tubular support is moveable from the first position to a second position, wherein in the second position the distal end of the tubular support is proximal to the anchor assembly, and movement of the tubular support from the first position to the second position draws the cover material inside-out such that the cover material extends proximally from the anchor assembly.

A method of sealing an opening within an anatomical wall, the method comprising:

• providing a sealing system comprising an elongate tubular support having a proximal end and a distal end, an anchor assembly provided over the elongate tubular support positioned between the proximal and distal ends, and a cover of bio-compatible material connected to the anchor assembly and extending distally therefrom to cover at least a portion of the tubular support;
• positioning the tubular support within the opening within the anatomical wall such that the proximal end of the tubular support is proximal of the opening and the distal end of the tubular support is distal of the opening, wherein the cover covering at least a portion of the tubular support extends at least distally of the opening;
• securing the anchor assembly to the anatomical wall adjacent the opening;
• moving the tubular support in a proximal direction so as to draw the cover material inside-out from a distal-most position wherein the cover extends at least distally of the opening to a proximal-most position wherein the cover extends proximally of the opening;
• and
• sealing a portion of the cover extending proximally of the opening.