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AssigneeWake Forest University Health Sciences
InventorsWilliam D. Wagner, Nicole Levi-Polyachenko, Tabitha Rosenbalm, Louis C. Argenta, Michael J. Morykwas
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A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.
A biphasic material comprising:
A tube configured to support a plurality of electric field gradients along its length, comprising a plurality of first tubular segments and a plurality of second tubular segments adjoined along a common axis of the tube, the first tubular segments comprising a first polymer component doped with a non-metal component which increases the conductivity of the first polymer component, and the second tubular segments comprising a second polymer component.
A method of making a tube configured to support a plurality of electric field gradients along its length, comprising the steps of:
An esterified polyglycerol sebacate polymer, the repeating structural unit of the esterified polyglycerol sebacate polymer having the formula
Dependencies are inferred from the claim text.