Sustained drug delivery from solid state compositions with nanochannel membranes
AssigneesThe Methodist Hospital Research Institute, Baylor College of Medicine
InventorsAlessandro Grattoni, Ganesh Subramanyam Palapattu, Mohit Khera
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Abstract
Implantable devices and methods for delivering pharmaceutical substances into a patient. The implantable device includes the following components: (a) an implant body, (b) a reservoir in the implant body, (c) a heterogeneous composition disposed in the reservoir, which includes a pharmaceutical substance in the solid state contacted by a solution of the pharmaceutical substance, and (d) a nanochannel membrane for delivering the pharmaceutical substance from the reservoir to a patient. Extended, high-quality delivery of low solubility drugs such as hormones and chemotherapeutic agents are achieved.
Claims27
An implantable device comprising:
- at least one implant body;
- at least one reservoir in said implant body;
- wherein inside the reservoir is disposed at least one pharmaceutical substance in a solid state contacted by at least one solution of said pharmaceutical substance, said solution comprising at least one solvent, and wherein said pharmaceutical substance in the solid state is in a form other than that of a suspension;
- and
- at least one nanochannel membrane for delivering said pharmaceutical substance from the reservoir to a patient.
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Dependencies are inferred from the claim text.