Hepatic neuromodulation to treat fatty liver conditions
AssigneeMetavention, Inc.
InventorsBobak Robert Azamian, Jonathan Allen Coe, Scott Bradley Vafai
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Abstract
According to some embodiments, a method of treating conditions affecting a liver of a subject is provided. The method may include delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.
Claims22
(canceled)
(canceled)
A method of treating conditions associated with a fatty liver or symptoms associated with a fatty liver, the method comprising:
- positioning a distal portion of an energy delivery device within a common hepatic artery of a subject,
- wherein the energy delivery device comprises one or more electrodes positioned at the distal portion of the energy delivery device;
- denervating a sympathetic nerve using the energy delivery device by intravascularly delivering energy to the inner wall of the common hepatic artery at a target location sufficient to treat a fatty liver condition,
- wherein the energy delivered by the energy delivery device comprises radiofrequency (RF) energy delivered by the one or more electrodes;
- and
- removing the energy delivery device from the subject.
A method of treating conditions associated with a fatty liver or symptoms associated with a fatty liver, the method comprising:
- positioning a distal end of a neuromodulation device within a hepatic artery segment;
- modulating one or more nerves that innervate the liver using the neuromodulation device sufficient to treat a fatty liver condition;
- and
- removing the neuromodulation device from the subject,
- wherein at least a portion of the distal end of the neuromodulation device is configured to contact the wall of the hepatic artery segment at a target location while the one or more nerves are being modulated.
A method of treating conditions associated with a fatty liver or symptoms associated with a fatty liver, the method comprising:
- providing an energy delivery device configured for:
- accessing a portion of vasculature in the vicinity of a hepatic plexus of a subject;
- and
- delivering energy through a wall of the vasculature sufficient to modulate one or more nerves of the hepatic plexus,
- wherein modulation of the one or more nerves is sufficient to treat a fatty liver condition.
Dependencies are inferred from the claim text.