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US 2015/0032044 A9Published application
Methods to regulate polarization and enhance function of cells
OwnerGholam A. Peymaninventor
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Abstract
Methods and compositions to controllably regulate cells at a target site. A quantum dot-targeting agent complex is administered to a patient in need of therapy, and the complex is stimulated using an implanted fiber optic system. In embodiments, the system includes an electrical sensor that detects and monitors electrical activity of the stimulated controllably regulated cells, and relays this information to a controller that can regulate further stimulation.
Claims25
A method to enhance functional recovery of a cell in a patient in need thereof, the method comprising
- administering to a patient in need thereof, in or with a biocompatible fluid, a plurality of nanoparticles selected from the group consisting of graphene quantum dots, graphene-oxide quantum dots, graphene-zinc oxide quantum dots, graphene nanotubes, carbon nanotubes, and combinations thereof, to a site containing a cell requiring functional recovery,
- controllably activating by light the nanoparticles at the site thus controllably altering at least one cellular electrical property using an internal device comprising
- a fiber optic comprising wires and a tip containing a light source,
- a sensor connectable to the fiber optic wires, and
- a controller to receive and generate electrical signals;
- sensing a signal resulting from the altered cellular electrical property at the site, and
- optionally providing the sensed signal to a processor to monitor and/or controllably alter the electrical property using the controller.
4 more elements
A method for providing therapy for a condition in a patient, the method comprising
- administering to a patient in need thereof a composition comprising
- nanoparticles comprising graphene quantum dots, graphene nanotubes, carbon nanotubes, hybrid quantum dots, or combinations thereof,
- an agent to target the complex to a specific site in the patient, and
- optionally a biomolecule,
- controllably activating the quantum dots at the site with localized light using a device comprising a light source, a battery, and a fiber optic comprising an electrical sensor;
- connecting the electrical sensor to a controller and sensing an electrical signal using graphene as a transistor;
- and
- optionally using the controller to controllably regulate an electrical property in a cell at the site.
5 more elements
Dependencies are inferred from the claim text.