Process for the preparation of dronedarone by oxidation of a sulphenyl group
AssigneeSanofi
InventorsCsaba Huszár, Adrienn Hegedus, Zsolt Dombrády
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Abstract
The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof which comprises oxidizing a compound of formula (IV) or a salt thereof with an oxidizing agent in an organic or inorganic solvent or solvent mixture, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (IV), and a process for the preparation thereof.
Claims7
Process for the preparation of dronedarone (I)
- and pharmaceutically acceptable salts thereof characterized in that a compound of formula (IV) or a salt thereof
- is oxidized with an oxidizing agent in an organic or inorganic solvent or solvent mixture,
- and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof.
The compound of formula (IV) and salts thereof
Process for preparation of compound of formula (IV) and salts thereof characterized in that a compound of formula (III)
- is reacted with a compound of formula (II)
- and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof.
Process according to claim 6 characterized in that the reaction is carried out in the presence of an organic or inorganic base catalyst.
Dependencies are inferred from the claim text.