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US 2015/0031875 A1Published application
Combined synthesis route for desogestrel and etonogestrel
AssigneeMSD Oss B.V.
InventorMartin Ostendorf
Life of this patent
Estimating the term…
Abstract
The present invention relates to a synthesis route and to steroid derivatives of general formula VI and VII useful in the synthesis of desogestrel and etonogestrel.
Claims15
A process for the manufacture of a steroid derivative according to general formula IX
- using a steroid derivative of general formula VI or VII
- wherein in the steroid derivatives of general formula VI, VII and IX, R1 and R2 are the same and are selected from H and (1-4C)alkyl;
- or R1 and R2, together with the sulphur atoms to which they are attached, form a 1,3-dithiolane or 1,3-dithiane, said dithiolane or dithiane being optionally substituted with one or more (1-4C)alkyl group;
- and
- R3 and R4 are the same and are selected from H and (1-4C)alkyl;
- or R3 and R4, together with the oxygen atoms to which they are attached, form a 1,3-dioxolane or 1,3-dioxane, said dioxolane or dioxane being optionally substituted with one or more (1-4C)alkyl group.
3 more elements
A steroid derivative of general formula VI or VII,
- wherein,
- R1 and R2 are the same and are selected from H and (1-4C)alkyl;
- or R1 and R2, together with the sulphur atoms to which they are attached, form a 1,3-dithiolane or 1,3-dithiane, said dithiolane or dithiane being optionally substituted with one or more (1-4C)alkyl group and R3 and R4 are the same and are selected from H and (1-4C)alkyl;
- or R3 and R4, together with the oxygen atoms to which they are attached, form a 1,3-dioxolane or 1,3-dioxane, said dioxolane or dioxane being optionally substituted with one or more (1-4C)alkyl group.
1 more element
Dependencies are inferred from the claim text.