Methods for reducing triglyceride, total cholesterol and low density lipoprotein blood levels
AssigneeMediciNova, Inc.
InventorKazuko MATSUDA
Life of this patent
Estimating the term…
Abstract
A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for reducing blood levels of one or more of triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL) in human subjects.
Claims36
A method of reducing a triglyceride blood level in a subject, comprising administering to a subject in need thereof an effective amount of a compound of Formula (I):
- a metabolite thereof, an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each of the foregoing, in which m is an integer from 2 to 5, n is an integer from 3 to 8, X1 and X2 each independently represent a sulfur atom, oxygen atom, sulfinyl group, or a sulfonyl group, provided that X1 and X2 cannot both be oxygen atoms.
A method of reducing a total cholesterol blood level in a subject, comprising administering to a subject in need thereof an effective amount of a compound of Formula (I):
- a metabolite thereof, an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each of the foregoing, in which m is an integer from 2 to 5, n is an integer from 3 to 8, X1 and X2 each independently represent a sulfur atom, oxygen atom, sulfinyl group, or a sulfonyl group, provided that X1 and X2 cannot both be oxygen atoms.
A method of reducing a low density lipoprotein (LDL) blood level in a subject, comprising administering to a subject in need thereof an effective amount of a compound of Formula (I):
- (I)
- a metabolite thereof, an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each of the foregoing, in which m is an integer from 2 to 5, n is an integer from 3 to 8, X1 and X2 each independently represent a sulfur atom, oxygen atom, sulfinyl group, or a sulfonyl group, provided that X1 and X2 cannot both be oxygen atoms.
Dependencies are inferred from the claim text.