Methods and compositions for neuroprotection
AssigneeQuark Pharmaceuticals, Inc.
InventorElena Feinstein
Life of this patent
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Abstract
Disclosed herein are methods and kits useful for providing neuroprotection to neurons in the inner ear and to methods of treating inner ear diseases and disorders, including tinnitus and Mnire's disease.
Claims71
A double-stranded RNA (dsRNA) compound which down regulates expression of a CASP2 gene encoding an mRNA having a sequence set forth in any one of SEQ ID NO:1-3, for use in neuroprotection of a neuron in the ear of a subject in need thereof.
A method of providing neuroprotection to a neuron in the ear of a subject in need thereof, comprising administering to the subject's ear a therapeutically effective amount of a double-stranded RNA (dsRNA) compound which down regulates expression of a CASP2 gene, wherein the CASP2 gene encodes a mRNA having a sequence set forth in any one of SEQ ID NO:1-3, so as to thereby provide neuroprotection to the neuron in the subject's ear.
A double-stranded RNA (dsRNA) compound which down regulates expression of a CAPNS1 gene encoding an mRNA having a sequence set forth in any one of SEQ ID NO:5-6, for use in neuroprotection of a neuron in the ear of a subject in need thereof.
A method of providing neuroprotection to a neuron in the ear of a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a double-stranded RNA (dsRNA) molecule which down regulates expression of a CAPNS1 gene, wherein the CAPNS1 gene encodes a mRNA having a sequence set forth in any one of SEQ ID NO:5-6, so as to thereby provide neuroprotection to the neuron in the subject's ear.
A double-stranded RNA (dsRNA) compound which down regulates expression of a NOX3 gene encoding an mRNA having a sequence set forth in SEQ ID NO:
- 4, for use in neuroprotection of a neuron in the ear of a subject in need thereof.
A method of providing neuroprotection to a neuron in the ear of a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a double-stranded RNA (dsRNA) molecule which down regulates expression of a NOX3 gene, wherein the NOX3 gene encodes a mRNA having a sequence set forth in SEQ ID NO:4, so as to thereby provide neuroprotection to the neuron in the subject's ear.
A double-stranded RNA (dsRNA) compound which down regulates expression of a RHOA gene encoding an mRNA having a sequence set forth SEQ ID NO:7, for use in neuroprotection of a neuron in the ear of a subject in need thereof.
A method of providing neuroprotection to a neuron in the ear of a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a double-stranded RNA (dsRNA) molecule which down regulates expression of a RHOA gene, wherein the RHOA gene encodes a mRNA having a sequence set forth in SEQ ID NO:7, so as to thereby provide neuroprotection to the neuron in the subject's ear.
A kit for providing neuroprotection to a neuron in an ear of a subject in need thereof comprising a dsRNA compound which down regulates expression of CASP2, NOX3, CAPNS1 or RHOA in the subject.
Dependencies are inferred from the claim text.