Heteroaryl Compounds and Methods of Use Thereof
AssigneeSunovion Pharmaceuticals Inc.
InventorsJohn Emmerson Campbell, Una Campbell, Taleen G. Hanania, Liming Shao
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Abstract
Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
Claims45
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein
- X is selected from S and O;
- one of R1a and R1b is a heterocyclic or heteroaryl ring;
- and the other of R1a and R1b is selected from hydrogen, halo, cyano, alkyl, alkoxyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, and heteroaryl;
- or
- R1a is a heterocyclic or heteroaryl ring;
- and taken together, R1b and R2 and the atoms to which they are attached form a cycloalkyl, aryl, heterocyclic or heteroaryl ring;
- and
- R2 and R3 are each independently selected from hydrogen, halo, cyano, alkyl, alkoxyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, and heteroaryl;
- or, taken together, R2 and R3 and the atoms to which they are attached form a cycloalkyl, aryl, heterocyclic or heteroaryl ring.
The compound of claim 20, wherein R1b is represented by the following structure:
The compound of claim 20, wherein R7 and R8 together with the atoms to which they are attached form an aryl, cycloalkyl, heterocyclyl, or heteroaryl ring.
The compound of claim 20, wherein R1b is represented by the following structure:
The compound of claim 20, wherein R1b is represented by the following structure:
Dependencies are inferred from the claim text.