Heterocyclic compounds for the inhibition of pask

A compound having structural formula IV:

• or a salt, ester or prodrug thereof, wherein:
• Rz is OH;
• R1 is chosen from aryl and heteroaryl, either of which may be optionally substituted with one or more substituents chosen from hydrogen, halo, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, aralkyl, heterocyclyl, heteroaryl, heterarylalkyl, CN, alkoxy, alkylamino, dialkylamino, NHSO2R12, NHSO2NHR12, NHCOR12, NHCONHR12, CONHR12, CONR12aR12b, hydroxy, SO2R12, SO2NHR12, CF3, and OCF3;
• R3 is hydrogen;
• R5 and R6 are independently chosen from hydrogen, C1-C6 alkyl, C1-C7 cycloalkyl, C1-C7 heterocycloalkyl, C1-C6 alkenyl, C1-C6 alkynyl, aryl, heteroaryl, aralkyl, and heteroaralkyl, or taken together, R5 and R6 may form a heterocycloalkyl or heteroaryl, any of which may be optionally substituted;
• R8 and R9 are each independently chosen from hydrogen, C1-C6 alkyl, aryl, heteroaryl, aralkyl and heteroaralkyl, any of which may be optionally substituted;
• and
• R12, R12a and R12b are independently chosen from hydrogen, C1-C6 alkyl, aryl, heteroaryl, aralkyl, CF3 and heteroaralkyl, any of which may be optionally substituted.