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US 2015/0031628 A1Published application
Methods and formulations for converting intravenous and injectable drugs into oral dosage forms
AssigneeZomanex, LLC
InventorCurtis A. Spilburg
Life of this patent
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Abstract
Oral dosage compositions for drugs normally given intravenously such as Paclitaxel, containing a plant sterol to enhance solubility and a small intestine efflux inhibitor to prevent P-glycoprotein from being a barrier to absorption.
Claims40
A drug delivery composition for normally difficultly soluble hydrophobic crystalline drug actives, comprising:
- an emulsifier, a plant derived sterol (stanol) or ester derived from the sterol (stanol);
- a drug active effective amount of a hydrophobic drug;
- and
- a small but inhibiting effective amount of an inhibitor of small intestine efflux proteins.
1 more element
The method of preparing a drug delivery system for normally difficultly soluble hydrophobic compounds, comprising:
- mixing together with a non-polar solvent an emulsifier(s) or mixtures thereof;
- a plant derived sterol (stanol) or esters derived from plant sterol (stanol) in which the fatty acid ester moiety is derived from a vegetable or tall oil;
- a drug active;
- and
- an inhibitor of the small intestinal drug efflux protein;
- removing the solvent to leave a solid residue of the mixed components;
- adding water to the solid residue of the mixed components at a temperature less than the decomposition temperature of any one of the mixed components;
- homogenizing the aqueous mixture;
- drying the homogenized mixture;
- and
- providing the dried solid residue of the mixed components in a solid pharmaceutical carrier format.
8 more elements
Dependencies are inferred from the claim text.