Water-soluble aie luminogens for monitoring and retardation of fibrillation of amyloid proteins

A method of monitoring amyloid protein fibrillation in a biological sample comprising contacting a water-soluble conjugated polyene compound that exhibits aggregation induced emission with the biological sample containing an amyloid protein;

• and detecting fluorescence emitted by said water-soluble conjugated polyene compound and the fluorescence emitted is induced by aggregation of said water-soluble conjugated polyene compound when contacting with said biological sample, wherein said water-soluble conjugated polyene compound is selected from the group consisting of:
• 1,2-Bis[4-(3-sulfonatopropoxy)phenyl]-1,2-diphenylethene sodium;
• 1,2-Bis[4-(3-triphenylphosphonium)phenyl]-1,2-diphenylethene bromide;
• 1-[4-(1-methyl-4-pyridine)ethene]-1,2,3-triphenylethene hexafluorophosphate;
• 1-[4-(1,2-dimethyl-5-benzothiazole)]-1,2,3-triphenylethene iodide;
• N,N′,N″,N′″-[1,2-tetrakis(1,4-phenoxyethyl)vinyl]tetrakis(trimethylammoniumbromide);
• 1-[4-(1-ethyl-2-benzothiazole)ethene]-1,2,3-triphenylethene hexafluorophosphate;
• and
• 1,1′-methyl-2,5-bis[4-(1-sulfonatopropyl-2-isoindole)ethenephenyl]-3,4-bisphenyl silole.