Compositions comprising a delivery agent and preparation thereof
AssigneeNovo Nordisk A/S
InventorThomas Vilhelmsen
Life of this patent
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Abstract
The invention relates to granules and pharmaceutical compositions comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant obtained by mixing hereof for more than 5 minutes prior to granulation as well as processes for their preparation and use thereof in medicine.
Claims16
A granule comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant, wherein said granule is obtained by mixing said salt of N-(8-(2-hydroxybenzoyl)amino)caprylic and said lubricant for more than 5 minutes prior to granulation.
A process of producing a granule comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant, such a magnesium stearate, wherein said process comprises the steps:
- a) mixing said salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and said lubricant for more than 5 minutes;
- and
- b) optionally roller compacting the mixture of step a.
(canceled)
Dependencies are inferred from the claim text.