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US 2015/0031601 A1Published application
Antimicrobial Peptide Variants and Polynucleotides Encoding Same
AssigneeAddenium Biotech Aps
InventorsHans-Henrik Kristensen Hoegenhaug, Per Holse Mygind, Thomas Kruse, Dorotea Raventos Segura, Dorthe Hoj Sandvang, Soren Neve
Life of this patent
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Abstract
The present invention relates to variants of a parent antimicrobial peptide. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
Claims16
An isolated variant of an antimicrobial peptide having the amino acid sequence of SEQ ID NO:
- 2, comprising a substitution at one or more positions 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 17, 19, and 21 of the amino acid sequence of SEQ ID NO:
- 2;
- wherein the variant has antimicrobial activity, and the number of substitutions is 1-11, wherein when said variant comprises a substitution selected from G1R or G1K, said variant further comprises a substitution at positions 5 or 17.
Dependencies are inferred from the claim text.