US 2015/0031127 A1 · SELF-ASSEMBLED NANOSTRUCTURES

Abstract

The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit nano structures.

Claims28

Dependent claims

A peptide segment comprising a first domain, a second domain and a third domain, wherein:

(a) the first domain comprises a moiety that has binding affinity for a charged compound, and is positioned at a first terminus of the second domain;
(b) the second domain comprises an amino acid sequence with a coiled-coil structure and is positioned between the first domain and the third domain;
and
(c) the third domain comprises a water soluble polymer and is positioned at a second terminus of the second domain,
wherein a plurality of peptide segments have the ability to self assemble to form a capsomer.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/342,245Filed 31 Aug 2012

Priority

2 Sep 2011

Published

29 Jan 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07K 14/001
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: by chemical synthesis
A61K 31/713
Compounds having three or more nucleosides or nucleotides: double-stranded nucleic acids or oligonucleotides
A61K 47/60
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes: the organic…
A61K 47/64
The modifying agent being a protein, peptide or polyamino acid: drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying…

Abstract

The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit nano structures.

Claims28

Dependent claims

A peptide segment comprising a first domain, a second domain and a third domain, wherein:

(a) the first domain comprises a moiety that has binding affinity for a charged compound, and is positioned at a first terminus of the second domain;
(b) the second domain comprises an amino acid sequence with a coiled-coil structure and is positioned between the first domain and the third domain;
and
(c) the third domain comprises a water soluble polymer and is positioned at a second terminus of the second domain,
wherein a plurality of peptide segments have the ability to self assemble to form a capsomer.

2 more elements

Dependencies are inferred from the claim text.

Self-assembled nanostructures

Life of this patent

Abstract

Claims28

Self-assembled nanostructures

Life of this patent

Abstract

Claims28