L-aspartate oxidase variant and a method for producing quinolinate or nicotinic acid using the same
AssigneeCj Cheiljedang Corporation
InventorsSo Young KIM, Yong Uk SHIN, In Kyung HEO, Ju Eun KIM, Kwang Ho NA, Chang Il SEO, Sung Kwang SON, Jae Hee LEE
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Abstract
To produce quinolinate effectively, a L-aspartate oxidase variant that the feedback regulation by nicotinic acid or NAD is released, and a microorganism including the L-aspartate oxidase variant are provided. Quinolinate may be effectively produced by culturing of the microorganism including the L-aspartate oxidase variant.
Claims11
An L-aspartate oxidase variant having an amino acid sequence of which a 302nd amino acid in an amino acid sequence represented by SEQ ID NO:
- 1 is substituted with another amino acid.
A polynucleotide comprising a nucleotide sequence that encoding an amino acid sequence which a 302nd amino acid in an amino acid sequence represented by SEQ ID NO:
- 1 is substituted with another amino acid.
Dependencies are inferred from the claim text.