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US 2015/0031050 A1Published application
Method of Screening Therapeutic Agent for Treating Inflammatory Diseases
AssigneeMacau University of Science and Technology
InventorsLiang LIU, Ting LI, Kam Wai WONG, Zhihong JIANG, Hua ZHOU
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Abstract
Uses and applications derived from the discovery of a novel binding site of IKK-β, such as method of screening a therapeutic agent as drug candidate for treating cancer, inflammation, or other diseases/disorders, are provided.
Claims6
A method of screening a drug candidate as a therapeutic agent for treating inflammatory diseases or as an IKK-β inhibitor comprising:
- a) exposing said drug candidate to an assay comprising IKK-β;
- b) detecting whether said drug candidate binds to cysteine-46 residue of IKK-β;
- c) detecting whether said drug candidate inhibits kinase activity of IKK-β upon said binding in step (b);
- and
- d) identifying said drug candidate as the therapeutic agent for treating inflammatory diseases or the IKK-β inhibitor if said drug candidate is detected to perform said binding action of step (b) and said inhibition action of step (c).
2 more elements
Dependencies are inferred from the claim text.