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US 2015/0031044 A1Published application
Gravitational fluctuation stress loading method, aircraft, aircraft-flying method, method for promoting serotonin-producing gene expression, serotonin-producing method, method for stimulating central nervous system, and efficacy-measuring method
AssigneeMitsubishi Heavy Industries, Ltd.
InventorsToshimasa OCHIAI, Mitsuhiro YOSHIOKA, Junichiro GYOTOKU, Hisashi OHTA
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Abstract
A gravitational fluctuation stress loading method capable of causing a new acute stress reaction in a subject or a laboratory animal is provided. A gravitational fluctuation stress loading method including at least one first stress-loading step (S1) of placing a stress load on the subject or the laboratory animal by means of microgravity is provided.
Claims2
1-10. (canceled)
A method for measuring an efficacy of a drug by promoting expression of a gene encoding a protein functionally involved in serotonin production, comprising:
- (1) a gravitational fluctuation stress loading step comprising:
- at least one microgravity stress-loading step of placing a stress load on a subject with microgravity,
- at least one hypergravity stress-loading step of placing a stress load on the subject with hypergravity, and
- at least one additional separate microgravity stress-loading step or hypergravity stress-loading step,
- wherein the microgravity stress-loading steps and the hypergravity stress-loading steps are performed alternately;
- (2) a drug administration step of administering a drug to the subject which targets serotonin selectively produced with the gene encoding the protein functionally involved in serotonin production due to a stress response caused by step (1), and
- (3) a measurement step of measuring the efficacy of the drug.
4 more elements
Dependencies are inferred from the claim text.