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US 2015/0030702 A1Published application
Nitric oxide-generating skin dressings
AssigneeInsense Limited
InventorsJan Jezek, Lynne Patricia Watson
Life of this patent
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Abstract
A skin dressing is provided comprising a first component including a source of protons, a second component including a nitrite salt, the skin dressing further comprising a non-thiol reductant. The skin dressing is adapted, such that, when the first and second components are brought together and applied to a skin site the nitrite reacts to generate nitric oxide, increasing the pH of the dressing in contact with the skin site from an acidic value to a more neutral value.
Claims20
A skin dressing comprising:
- a first component including a source of protons;
- a second component including a nitrite salt;
- and
- a non-thiol reductant;
- wherein the skin dressing is adapted such that, when the first and second components are brought together and applied to a skin site, the nitrite reacts to generate nitric oxide, increasing a pH of the skin dressing in contact with the skin site from an acidic value to a more neutral value;
- and
- wherein the source of protons includes a buffer with a pKa of from 4.5 to 7.0.
4 more elements
A skin dressing comprising:
- a first component including a non-thiol reductant and a buffer with a pKa of from 4.5 to 7.0;
- and
- a second component including a nitrite salt;
- wherein the skin dressing is adapted, when the first component and the second component are brought together and applied to a skin site, to generate nitric oxide by reacting the nitrite, and to increase a pH of the skin dressing in contact with the skin site from an acidic value to a more neutral value.
1 more element
Dependencies are inferred from the claim text.