Formulations and methods for treating oral inflammation, injury, or pain
AssigneeRutgilli Pharmaceuticals, LLC
InventorsEdward D. Kobus, Bartholomew Weldon
Life of this patent
Estimating the term…
Abstract
The present invention generally relates to formulations and methods for treating oral inflammation, oral injury and/or oral pain by applying hydrogel, viscous liquid, or other formulation to the oral cavity. Wet formulations comprise a hydrophilic polymer selected from the group consisting of pyrrolidones, hyaluronic acid and salts thereof, alginic acid and salts thereof, and carrageenans and salts thereof; calcium salts or ions, phosphate salts or ions, and water as well as other optional components. Dry formulations such as powders are also contemplated.
Claims20
A dry formulation adapted for reconstituting with water to form a liquid formulation for treating oral injury, oral inflammation and/or oral pain, the dry formulation comprising:
- one or more hydrophilic polymers, at least one of which is selected from the group consisting of:
- pyrrolidones,
- hyaluronic acids and salts thereof;
- alginic acids and salts thereof;
- carrageenans and salts thereof;
- celluloses;
- dextrins;
- and mixtures thereof;
- wherein said hydrophilic polymers are present in an amount between 4% to 85%, based on the total weight of the dry formulation;
- from 2.5% to 7% by weight, based on the total weight of the dry formulation, of one or more calcium salts;
- and
- from 0.4% to 1.2% by weight, based on the total weight of the dry formulation, of one or more phosphate salts.
A wet formulation for treating oral injury, oral inflammation and/or oral pain, the formulation comprising:
- one or more hydrophilic polymers, at least one of which is selected from the group consisting of
- pyrrolidones,
- hyaluronic acids and salts thereof;
- alginic acids and salts thereof;
- carrageenans and salts thereof;
- celluloses;
- dextrins;
- and mixtures thereof;
- wherein said hydrophilic polymers are present in an amount between 1% to 15%, based on the total weight of the wet formulation;
- at least 10,000 ppm of calcium ions;
- at least 5,000 ppm of phosphate ions;
- and
- water.
Dependencies are inferred from the claim text.