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US 2015/0030682 A1Published application
Antigenic compositions and methods
AssigneeArtificial Cell Technologies, Inc.
InventorsThomas J. Powell, James Gorham Boyd
Life of this patent
Estimating the term…
Abstract
Multilayer films comprised of polypeptide epitopes and a toll-like receptor ligand. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes one or more polypeptide epitopes from a virus, bacteria, fungus or parasite.
Claims22
A composition comprising
- a first multilayer film comprising a plurality of oppositely charged polyelectrolyte layers, wherein one of the polyelectrolyte layers in the multilayer film comprises a first antigenic polyelectrolyte, wherein the first antigenic polyelectrolyte comprises a viral, bacterial, fungal or parasite polypeptide epitope,
- wherein the multilayer film comprises a toll-like receptor ligand, and
- wherein the polyelectrolytes in the multilayer film comprise a polycationic material or a polyanionic material having a molecular weight of greater than 1,000 and at least 5 charges per molecule.
A composition comprising
- a first multilayer film comprising a plurality of oppositely charged polyelectrolyte layers, wherein one of the polyelectrolyte layers in the first multilayer film comprises a first antigenic polyelectrolyte, wherein the first antigenic polyelectrolyte comprises a viral, bacterial, fungal or parasite polypeptide epitope,
- a second multilayer film comprising a plurality of oppositely charged polyelectrolyte layers wherein one of the polyelectrolyte layers in the second multilayer film comprises a second polyelectrolyte, wherein the second polyelectrolyte comprises a toll-like receptor ligand, and
- wherein the polyelectrolytes in the first and second multilayer films comprise a polycationic material or a polyanionic material having a molecular weight of greater than 1,000 and at least 5 charges per molecule.
Dependencies are inferred from the claim text.