Tamper Resistant Immediate Release Formulations
AssigneeRhodes Pharmaeuticals L.P.
InventorsAkwete L. Adjei, Sibao Chen, Robert J. Kupper, Vincent Mancinelli
Life of this patent
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Abstract
Disclosed is an immediate release solid oral dosage form comprising (i) an active agent; and (ii) a material that is sensitive to acidic pH;
Claims24
An immediate release solid oral dosage form comprising a plurality of particles, each particle comprising:
- (i) an active agent;
- and
- (ii) a material that is sensitive to acidic pH;
- wherein the dosage form releases at least about 70% of the active agent within 45 minutes as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at 50 rpm in 500 ml 0.1 N HCl at 37° C.
17-36. (canceled)
39-69. (canceled)
A process for preparing an immediate release solid oral dosage form comprising:
- (i) preparing a plurality of particles, each particle comprising an active agent and a material that is sensitive to acidic pH;
- and
- (ii) dispersing the plurality of particles into a matrix;
- wherein the dosage form releases at least about 70% of the active agent within 45 minutes as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at 50 rpm in 500 ml 0.1 N HCl at 37° C.
71-83. (canceled)
A method of treating pain comprising administering to a patient in need thereof, an immediate release solid oral dosage form comprising a plurality of particles, each article comprising:
- (i) an active agent;
- and
- (ii) a material that is sensitive to acidic pH;
- wherein the dosage form releases at least about 70% of the active agent within 45 minutes as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at 50 rpm in 500 ml 0.1 N HCl at 37° C.
85-102. (canceled)
Dependencies are inferred from the claim text.