Liposome having inner water phase containing sulfobutyl ether cyclodextrin salt
AssigneeCspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.
InventorsChunlei LI, Lan ZHANG, Caixia WANG, Li ZHANG, Dongmin SHEN, Yanhui LI, Xian XIU, Min LIANG, Yongfeng LI
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Abstract
A liposome comprising bilayer and inner water phase is disclosed. Said inner water phase may contain sulfobutyl ether cyclodextrin and an active compound.
Claims18
A liposome comprising bilayer, inner water phase and metal cation ionophore, wherein the inner water phase comprises a salt of sulfobutyl ether cyclodextrin and an active compound.
A liposome comprising bilayer and inner water phase, wherein the inner water phase comprises a salt of sulfobutyl ether cyclodextrin and an active compound, and wherein the salt of sulfobutyl ether cyclodextrin is formed by sulfobutyl ether cyclodextrin with one or more of ammonium hydroxide, triethylamine and triethanolamine.
A process for preparing a liposome comprising:
- (1) hydrating lipid phase powders with aqueous solution of sulfobutyl ether cyclodextrin or its salt, to form a blank liposome comprising an aqueous solution of sulfobutyl ether cyclodextrin or its salt as inner water phase,
- (2) removing the salt of sulfobutyl ether cyclodextrin in the outer phase of the blank liposome, to form an anion gradient,
- (3) adding a metal cation ionophore to the outer phase of the blank liposome, to form a pH gradient, and
- (4) incubating the blank liposome with the active compound in aqueous solution, to encapsulate the active compound into the liposome.
Dependencies are inferred from the claim text.