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US 2015/0030670 A1Published application
Aminoacid lipids
AssigneeMerck Patent GmbH
InventorsMichael Wilhelm Platscher, Raymond Behrendt, Viola Groehn, Simone Rachel Hoertner, Marco Silvio Passafaro, Finn Bauer
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Abstract
The present invention is directed to a new class of lipids, more specifically ether-lipids having a polar headgroup, as well as vesicles comprising these lipids, methods of their preparation as well as their uses in medical applications, wherein the ether-lipids are represented by general formula I
Claims19
A compound of general formula I
- wherein
- Y represents O, N, S or a covalent bond,
- P1 represents H, an Y-protecting group or an Y-activating group or a spacer group,
- P2, P3 represent independently of each other H, an amino-protecting group or a spacer group, or P2 and P3 form together with the N to which they are bound a ring structure,
- L is a group of formula (a)
- wherein the dashed line represents the linkage to N,
- R1, represent H or a group of formula —(CH2)2—ORb1,
- R1′, represent H or a group of formula —(CH2)2—ORb2,
- R2 represents H or a group of formula —CH2—ORc,
- R2′ represents H or a group of formula —ORd or —CH2—ORd,
- R3 represents H or a group of formula —(CH2)2—ORe or —(CH2)3—ORe,
- Ra, Rb1, Rb2, Rc, Rd, Re represent independently of each other a saturated or unsaturated, straight or branched hydrocarbon chain,
- m is 1, 2 or 3,
- with the proviso that at least one of R1, R1′, R2, R2′, R3 is not H.
11 more elements
Dependencies are inferred from the claim text.