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US 2015/0030658 A1Published application
Generation of photoreceptors from human retinal progenitor cells using polycaprolactone substrates
AssigneeThe Schepens Eye Research Institute, Inc.
InventorsCaio Regatieri, Petr Y. Baranov, Michael J. Young
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Abstract
The present invention relates to biocompatible compositions for transplantation into a sub-retinal space of the human eye. The compositions include a biodegradable polyester film, preferably a polycaprolactone (PCL) film, and a layer of human retinal progenitor cells. The compositions of the invention can be used as scaffolds for the treatment a number of ocular diseases, including retinitis pigmentosa and age-related macular degeneration.
Claims38
A biocompatible composition comprising:
- a biodegradable and biocompatible polyester carrier film, and
- a layer of isolated human retinal progenitor cells and/or derivatives thereof adhered to at least a portion of the surface of said polyester film.
A method for culturing human retinal progenitor cells, comprising
- depositing a layer of isolated human retinal progenitor cells and/or derivatives thereof on a biodegradable and biocompatible polyester carrier film under conditions to adhere the isolated cells to the carrier film, and
- culturing the cells.
Dependencies are inferred from the claim text.