Smooth muscle cell constructs

An implantable cell-scaffold construct for treating a subject in need comprising

• a) a scaffold comprising a matrix having a first surface, wherein the matrix is shaped to allow the passage of urine from a native vessel in a subject in need;
• and
• b) a first cell population derived from a source that is non-autologous to the subject and is not the native organ or tissue structure deposited on or in the first surface, said matrix and said first cell population forming an implantable construct.

An implantable cell-scaffold construct for treating a respiratory disorder in a subject in need comprising:

• (a) a scaffold comprising a matrix having a first surface, wherein the matrix is shaped to conform to at least a part of a native respiratory organ or tissue structure in the subject;
• (b) a first cell population that is not derived from respiratory tissue deposited on or in the first surface, said matrix and said first cell population forming an implantable construct.

An implantable cell-scaffold construct for treating a gastrointestinal disorder in a subject in need comprising

• a) a scaffold comprising a matrix having a first surface, wherein the matrix is shaped to conform to at least a part of a native gastrointestinal organ or tissue structure in the subject;
• and
• b) a first cell population that is not derived from a gastrointestinal source deposited on or in the first surface, said scaffold and said first cell population forming an implantable construct.

5-32. (canceled)

The construct of claim 50, wherein the GI cell population is selected from the group consisting of an esophageal cell population, a small intestinal cell population, a large intestinal cell population, a stomach cell population, a colon cell population, and an anal sphincter cell population.