# US 2015/0030648 A1 · Dispersion intended for encapsulating an active product and associated use

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- Number: US 2015/0030648 A1
- Document ID: US20150030648A1
- Status: Published application
- Kind: A1
- Application number: 14/383,186
- Filed: 2013-03-08
- Published: 2015-01-29
- Earliest claimed: 2012-03-08
- Assignees: Capsum
- Applicants: Capsum
- Inventors: Jérôme Bibette; Thomas Delmas; Enric Santanach Carreras; Leslie Rolland
- Web page: https://patentgrep.com/patent/US20150030648A1

## CPC

- A61K 9/10: Dispersions; Emulsions
- A23P 10/30: Encapsulation of particles, e.g. foodstuff additives
- A61K 8/04: Dispersions; Emulsions
- A61K 8/11: Encapsulated compositions
- A61Q 19/00: Preparations for care of the skin
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K 2800/10: General cosmetic use
- A61K 2800/56: Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
- A61K 2800/63: More than one coating
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23P: SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A dispersion including a plurality of bodies dispersed in a continuous phase. Each dispersed body including an internal drop formed with an internal phase miscible with the continuous phase, the internal drop (16) receiving an active product. Each dispersed body including, around the internal drop, a membrane formed with an intermediate phase immiscible with the continuous phase and totally surrounding the internal drop. The ratio R1 of the average thickness (e) of the membrane over the average transverse dimension (Dc) of the active volume delimited by the internal drop and the membrane is greater than 0.05, and is advantageously less than 0.5. The ratio R2 of the partition coefficient of the active product between the intermediate phase forming the membrane and the internal phase forming the internal drop over the viscosity of the membrane is less than 1 s−1·Pa−1.

## Claims

### Claim at position 1

1-15. (canceled)

### Claim 16

A dispersion comprising a plurality of dispersed bodies in a continuous phase, each dispersed body including an internal drop formed with an internal phase, the internal drop receiving an active product, each dispersed body including, around the internal drop, a membrane formed with an intermediate phase and totally surrounding the internal drop,
wherein the ratio R1 of the average thickness of the membrane over the average transverse dimension of the active volume delimited by the internal drop and the membrane is greater than 0.05, and is advantageously less than 0.5,
and wherein the ratio R2 of the partition coefficient of the active product between the intermediate phase forming the membrane and the internal phase forming the internal drop over the viscosity of the membrane is less than 1 s−1·Pa−1.

### Claim 17 (depends on 16)

The dispersion according to claim 16, wherein the ratio R1 of the average thickness of the membrane over the average transverse dimension of the active volume is comprised between 0.08 and 0.45,
and in that the ratio R2 of the partition coefficient of the active product between the membrane and the internal drop over the viscosity of the membrane is less than 0.5 s−1·Pa−1.

### Claim 18 (depends on 16)

The dispersion according to claim 16, wherein the active volume of each dispersed body has an average transverse dimension greater than 0.5 mm.

### Claim 19 (depends on 16)

The dispersion according to claim 16, wherein the internal drop is formed by an aqueous internal phase, the membrane being formed by an oily intermediate phase.

### Claim 20 (depends on 19)

The dispersion according to claim 19, wherein the oily phase is formed from an oil selected from the group comprising silicone oils, mineral oils, fatty acid and/or fatty alcohol esters, vegetable oils, and oils compatible with esters, their mixtures and/or their gelled form.

### Claim 21 (depends on 16)

The dispersion according to claim 16, wherein the thickness deviation of the membrane over the whole outer surface of the internal drop is less than 30%.

### Claim 22 (depends on 16)

The dispersion according to claim 16, wherein each dispersed body includes an external casing surrounding the membrane, the external casing having a thickness of less than that of the membrane.

### Claim 23 (depends on 22)

The dispersion according to claim 22, wherein the external casing is formed with a gelled polyelectrolyte layer.

### Claim 24 (depends on 16)

The dispersion according to claim 16, wherein the active product is selected from a cosmetic active product, a biologically active product or an edible active product or mixtures thereof.

### Claim 25 (depends on 16)

The dispersion according to claim 16, wherein the membrane is liquid or is made on the basis of a thixotropic phase.

### Claim 26 (depends on 16)

The use of a dispersion according to claim 16 for encapsulating an active product for a period of more than one week.

### Claim 27 (depends on 16)

The dispersion according to claim 16, wherein the ratio R1 of the average thickness of the membrane over the average transverse dimension of the active volume delimited by the internal drop and the membrane is less than 0.5.

### Claim 28 (depends on 17)

The dispersion according to claim 17, wherein the ratio R1 of the average thickness of the membrane over the average transverse dimension of the active volume delimited by the internal drop and the membrane is comprised between 0.1 and 0.4, and the ratio R2 of the partition coefficient of the active product between the membrane and the internal drop over the viscosity of the membrane is less than 0.2 s−1·Pa−1.

### Claim 29 (depends on 18)

The dispersion according to claim 18, wherein the active volume of each dispersed body has an average transverse dimension comprised between 1 mn and 5 mn.

### Claim 30 (depends on 26)

The use according to claim 26 wherein the period is of more than one month.