US 2015/0030638 A1 · Ingenol Derivatives in the Reactivation of Latent HIV

Abstract

The present invention broadly relates to the use of certain ingenol derivatives as HIV reactivators of latent HIV virus in viral reservoirs. In another aspect, the present invention relates to an association comprising such ingenol derivatives and antiretroviral agents substantially active against actively replicating virus.

Claims20

Dependent claims

Use of one or more ingenol derivatives of formula I

in the preparation of a product useful in the treatment of HIV virus infection or AIDS treatment, wherein Z is Z1 or Z2 as follows:
such that when Z=Z1
x and y are integers, x varies between 2 and 10 and y varies between 2 and 7;
and when Z=Z2,
A is phenyl, CH3— or CH2=CH—,
and (B) is —CH=CH—, [—CH2—]q or [—CH2—]w,
wherein q is an integer varying between 1 and 10, preferably between 2 and 6, and w is an integer varying between 1 and 10, preferably between 8 and 10,
provided that:
when A is phenyl, B is —CH═CH—;
when A is CH3—, B is [—CH2—]q;
when A is CH2=CH—, B is [—CH2—]w

8 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/382,060Filed 1 Mar 2013

Priority

BR 10 2012 0047392 Mar 2012

Published

29 Jan 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 31/232
Of acids having a carboxyl group bound to a chain of seven or more carbon atoms: having three or more double bonds, e.g. etretinate
A61K 31/216
Of carboxylic acids: of acids having aromatic rings, e.g. benactizyne, clofibrate
A61K 31/22
Of carboxylic acids: of acyclic acids, e.g. pravastatin
A61K 31/23
Of acyclic acids, e.g. pravastatin: of acids having a carboxyl group bound to a chain of seven or more carbon atoms

Abstract

Claims20

Dependent claims

Use of one or more ingenol derivatives of formula I

in the preparation of a product useful in the treatment of HIV virus infection or AIDS treatment, wherein Z is Z1 or Z2 as follows:
such that when Z=Z1
x and y are integers, x varies between 2 and 10 and y varies between 2 and 7;
and when Z=Z2,
A is phenyl, CH3— or CH2=CH—,
and (B) is —CH=CH—, [—CH2—]q or [—CH2—]w,
wherein q is an integer varying between 1 and 10, preferably between 2 and 6, and w is an integer varying between 1 and 10, preferably between 8 and 10,
provided that:
when A is phenyl, B is —CH═CH—;
when A is CH3—, B is [—CH2—]q;
when A is CH2=CH—, B is [—CH2—]w

8 more elements

Dependencies are inferred from the claim text.

Ingenol Derivatives in the Reactivation of Latent HIV

Life of this patent

Abstract

Claims20

Ingenol Derivatives in the Reactivation of Latent HIV

Life of this patent

Abstract

Claims20