Gas57 mutant antigens and gas57 antibodies
AssigneeNovartis AG
InventorsImmaculada Margarit Y Ros, Guido Grandi, Chiara Zingaretti
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Abstract
The invention provides mutants of GAS57 (Spy0416) which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
Claims11
A mutant Spy0416 antigen comprising the amino acid sequence SEQ ID NO:1 but for an amino acid substitution at one or more amino acid positions selected from the group consisting of amino acids D151, H279, and S617.
Dependencies are inferred from the claim text.