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AssigneesCalder Biosciences Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsChristopher Patrick Marshall, Jason Scott McLellan, Peter Joseph Alff, Claudio Bertuccioli, Roberto Mariani
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In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.
A RSV F polypeptide, protein or protein complex comprising an amino acid sequence having at least 70% sequence identity to amino acid residues 1-513 of SEQ ID NO.1 (RSV type A) or amino acid residues 1-513 of SEQ ID NO.3 (RSV type B), wherein the amino acid sequence comprises a point mutation to tyrosine at one or more of amino acid positions 77, 88, 97, 147, 150, 155, 159, 183, 185, 187, 220, 222, 223, 226, 255, 427 or 469.
Dependencies are inferred from the claim text.