Increasing taxane sensitivity in cancer cells
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorRatna Chakrabarti
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Abstract
Disclosed herein are combinatorial therapies for treating or preventing reoccurrence of cancer. The therapies involve inhibition of LIMK1 in conjunction with taxane therapy. Specifically exemplified herein is co-administration of a LIMK1 RNA interfering molecule along with administration of a taxane.
Claims27
A method for treating cancer in a subject, said method comprising administering a taxane therapy to said subject, and co-administering a therapeutically effective amount of a LIMK1 inhibitor to said subject.
A method of treating chemotherapy resistant cells in a subject, the method comprising inhibiting LIMK1 in cells of said subject in conjunction with administering a chemotherapeutic agent.
A pharmaceutical composition comprising a LIMK1 inhibitor and a chemotherapeutic agent in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.