Influenza hemagglutinin-specific monoclonal antibodies for preventing and treating influenza virus infection
AssigneeNew York Blood Center, Inc.
InventorsShibo Jiang, Lanying DU, Yusen Zhou
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Abstract
Disclosed herein are neutralizing antibodies with cross-neutralizing activity and cross-protective effects against divergent stains of influenza virus, which are specific for an epitope having at least 90% homology to amino acids +72-115 of the HA1 domain of H5N1 influenza virus hemagglutinin.
Claims9
A neutralizing antibody specifically binding an epitope of the HA1 domain of influenza virus H5N1 hemagglutinin, the epitope having an amino acid sequence of SEQ ID NO:15, and wherein the antibody competes for specific binding to SEQ ID NO:15 with a murine monoclonal antibody secreted by hybridoma HA-3 (ATCC accession number PTA-12174) or hybridoma HA-7 (ATCC accession number PTA-12173).
Dependencies are inferred from the claim text.